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KMID : 1188320180120030324
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Gut and Liver
2018 Volume.12 No. 3 p.324 ~ p.330
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Daclatasvir Plus Asunaprevir for the Treatment of Patients with Hepatitis C Virus Genotype 1b Infection: Real-World Efficacy, Changes in Liver Stiffness and Fibrosis Markers, and Safety
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Lee Hye-Won
Oh Se-Rim
Kim Dong-Yun
Jeong Ye-Chan
Kim Seung-Taek
Kim Beom-Kyung
Kim Seung-Up
Kim Do-Young
Ahn Sang-Hoon
Han Kwang-Hyub
Park Jun-Yong
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Abstract
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Background/Aims: The treatment with daclatasvir plus asunaprevir (DCV+ASV) is associated with potent antiviral effects in patients with genotype 1b hepatitis C virus (HCV) infection. We investigated the real-world efficacy, changes in liver stiffness and noninvasive fibrosis markers, and the safety of DCV+ASV treatment in Korean patients.
Methods: In total, 363 patients with chronic hepatitis C were treated with DCV+ASV between August 2015 and January 2017. Finally, we analyzed the data of 270 patients who were monitored for at least 12 weeks after the end of treatment.
Results: The mean age was 60.7 years, and females predominated (60.4%). Most patients (64.8%) were treatment-naive, and 56 patients (20.7%) had cirrhosis. Two hundred fifty-seven (95.2%) and 251 (93.0%) patients achieved end-of-treatment responses and sustained virological responses at 12 weeks posttreatment (SVR12), respectively. The SVR12 rates were higher in patients who were ＜65 years of age, males, without cirrhosis and had lower HCV RNA levels. All LS values and fibrosis-4 and aspartate aminotransferase-to-platelet ratio index values declined from baseline to the time of assessment of SVR12.
Conclusions: The DCV+ASV therapy resulted in a high SVR12 and improved liver fibrosis; the treatment was well tolerated in patients with genotype 1b HCV infections.
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KEYWORD
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Daclatasvir, Asunaprevir, Hepatitis C, Genotype 1b, Fibrosis
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